Genetic ancestry, self-reported race and ethnicity in African Americans and European Americans in the PCaP cohort.

Genetic ancestry, self-reported race and ethnicity in African Americans and European Americans in the PCaP cohort.

Blog Article

Family history and African-American race are important risk factors for both prostate cancer (CaP) incidence and aggressiveness.When studying complex diseases such as CaP that have a heritable component, chances of finding true disease susceptibility alleles can be increased by accounting for genetic ancestry within the population investigated.Race, ethnicity and ancestry were studied in a geographically diverse cohort of men with newly diagnosed CaP.

Individual ancestry (IA) was estimated in the population-based North Carolina and Louisiana Prostate Cancer Project (PCaP), a cohort of 2,106 incident CaP Set of 4 Mugs cases (2063 with complete ethnicity information) comprising roughly equal numbers of research subjects reporting as Black/African American (AA) or European American/Caucasian/Caucasian American/White (EA) from North Carolina or Louisiana.Mean genome wide individual ancestry estimates of percent African, European and Asian were obtained and tested for differences by state and ethnicity (Cajun and/or Creole and Hispanic/Latino) using multivariate analysis of variance models.Principal components (PC) were compared to assess differences in genetic composition by self-reported race and ethnicity between and within states.

Mean individual ancestries differed by state for self-reporting AA (p = 0.03) and EA (p = 0.001).

This geographic difference attenuated for AAs who answered "no" to all ethnicity membership questions (non-ethnic research subjects; p = 0.78) but not EA research subjects, p = 0.002.

Mean ancestry estimates of self-identified AA Louisiana research subjects for each ethnic group; Cajun only, Creole only and both Cajun and Creole differed significantly from self-identified non-ethnic AA Louisiana research subjects.These ethnicity differences were not seen in those who self-identified as EA.Mean IA differed by race between states, elucidating a potential contributing factor to these differences in AA research participants: Deviled Egg Holder self-reported ethnicity.

Accurately accounting for genetic admixture in this cohort is essential for future analyses of the genetic and environmental contributions to CaP.